Bromide ion → 1-(4-chlorobenzyl)-5-(4-(2-hydroxypropan-2-yl)phenyl)pyridin-2(1H)-one

Reaction equation

[Br-:25].[CH2:28]1[O:29][CH2:30][CH2:31][CH2:32]1.[CH3:26][Mg+:27].[Cl:1][c:2]1[cH:3][cH:4][c:5]([CH2:6][n:7]2[c:8](=[O:22])[cH:9][cH:10][c:11](-[c:13]3[cH:14][cH:15][c:16]([C:19]([CH3:20])=[O:21])[cH:17][cH:18]3)[cH:12]2)[cH:23][cH:24]1>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([CH2:6][n:7]2[c:8](=[O:22])[cH:9][cH:10][c:11](-[c:13]3[cH:14][cH:15][c:16]([C:19]([CH3:20])([OH:21])[CH3:26])[cH:17][cH:18]3)[cH:12]2)[cH:23][cH:24]1

Participants

Reactant 4

HCID 259Bromide ion

HCID 8028Tetrahydrofuran

HCID 69349823HCID 69349823, compound

HCID 178477777HCID 178477777, compound

Product 1

HCID 589669181-(4-chlorobenzyl)-5-(4-(2-hydroxypropan-2-yl)phenyl)pyridin-2(1H)-one

Sources & evidence

ORD record: ord-9e1dd6261c3f4eeb9cdb650fa6594f03
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (7/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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