Methanol → 3-Methyl-1,6-diazaspiro[3.4]octane-1-carboxylic acid tert-butyl ester

Reaction equation

[C+4:31].[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH:10]([CH3:23])[C:11]12[CH2:12][N:13]([CH2:16][c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1)[CH2:14][CH2:15]2.[CH3:24][OH:25].[O:26]1[CH2:27][CH2:28][CH2:29][CH2:30]1.[OH-:32].[OH-:34].[OH-:35].[OH-:36].[OH-:37].[OH-:38].[Pd+2:33]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH:10]([CH3:23])[C:11]12[CH2:12][NH:13][CH2:14][CH2:15]2

Participants

Reactant 6

HCID 887Methanol

HCID 961Hydroxide6×

HCID 8028Tetrahydrofuran

HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)

HCID 58293367HCID 58293367, compound

HCID 178420935HCID 178420935, compound

Product 1

Sources & evidence

ORD record: ord-fd4e1901f2fb42d6b7bd2a7b01230060
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (7/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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