Dichloromethane → AZD5363 (Capivasertib)

HRID 1139709Notes

Reaction equation

HRID 1139709 reaction equation
[Cl:45][CH2:46][Cl:47].[Cl:8][c:9]1[cH:10][cH:11][c:12]([CH:15]([CH2:16][CH2:17][OH:18])[NH:19][C:20](=[O:21])[C:22]2([NH:37][C:38](=[O:39])[O:40][C:41]([CH3:42])([CH3:43])[CH3:44])[CH2:23][CH2:24][N:25]([c:28]3[c:29]4[c:30]([n:31][cH:32][n:33]3)[nH:34][cH:35][cH:36]4)[CH2:26][CH2:27]2)[cH:13][cH:14]1.[F:1][C:2]([F:3])([F:4])[C:5]([OH:6])=[O:7]>>[Cl:8][c:9]1[cH:10][cH:11][c:12]([CH:15]([CH2:16][CH2:17][OH:18])[NH:19][C:20](=[O:21])[C:22]2([NH2:37])[CH2:23][CH2:24][N:25]([c:28]3[c:29]4[c:30]([n:31][cH:32][n:33]3)[nH:34][cH:35][cH:36]4)[CH2:26][CH2:27]2)[cH:13][cH:14]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 57750387tert-butyl 4-(1-(4-chlorophenyl)-3-hydroxypropylcarbamoyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-ylcarbamate

Product 1

HCID 42602260AZD5363 (Capivasertib)

Sources & evidence

ORD record
ord-5dc5447997674fcbb0645c75cfc53d31
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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