Benzo(B)Thiophene-2-Boronic Acid → 3-[(Aminocarbonyl)amino]-5-(1-benzothien-2-yl)thiophene-2-carboxamide

Reaction equation

[NH2:1][C:2]([NH:4][C:5]1[CH:9]=[C:8](Br)[S:7][C:6]=1[C:11]([NH2:13])=[O:12])=[O:3].[S:14]1[C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=2[CH:16]=[C:15]1B(O)O>>[NH2:1][C:2]([NH:4][C:5]1[CH:9]=[C:8]([C:15]2[S:14][C:18]3[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=3[CH:16]=2)[S:7][C:6]=1[C:11]([NH2:13])=[O:12])=[O:3]

Participants

Reactant 2

HCID 2359Benzo(B)Thiophene-2-Boronic Acid

HCID 219758555-Bromo-3-ureidothiophene-2-carboxamide

Product 1

HCID 219758573-[(Aminocarbonyl)amino]-5-(1-benzothien-2-yl)thiophene-2-carboxamide

Procedure

The title compound was prepared from 3-[(aminocarbonyl)amino-5-bromothiophene-2-carboxamide and 1-benzothien-2-ylboronic acid in a similar manner to Example 11 (g).

Sources & evidence

ORD record: ord-adc4df26b1f04203ac53fb02abc42a4f
Source dataset: uspto-grants-2006_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07098240B2

Reaction notes

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