Chloride → 4-Chloro-2-fluoro-5-methoxybenzyl chloride

HRID 1149355Notes

Reaction equation

HRID 1149355 reaction equation
[CH3:11][O:12][CH2:13][Cl:14].[Cl-:19].[Cl-:20].[Cl-:21].[Cl-:22].[Cl:16][CH2:17][Cl:18].[Cl:1][c:2]1[c:3]([O:9][CH3:10])[cH:4][cH:5][c:6]([F:8])[cH:7]1.[OH2:15].[Ti+4:23]>>[Cl:1][c:2]1[c:3]([O:9][CH3:10])[cH:4][c:5]([CH2:13][Cl:14])[c:6]([F:8])[cH:7]1

Participants

7

Reactant 6

HCID 312Chloride4×HCID 962WaterHCID 6344DichloromethaneHCID 7864Chloromethyl Methyl EtherHCID 114942Titanium cation (4+)HCID 27735802-Chloro-4-fluoroanisole

Product 1

HCID 184083444-Chloro-2-fluoro-5-methoxybenzyl chloride

Sources & evidence

ORD record
ord-df99271b1e294481bd5d907f9e059eec
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (7/10)

Reaction notes

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