Water → [4-(Spiro[indane-1,4'-piperidine]-1'-ylmethyl)phenyl]methanol

Reaction equation

[Br:21][CH2:22][c:23]1[cH:24][cH:25][c:26]([CH2:29][OH:30])[cH:27][cH:28]1.[C:15](=[O:16])([O-:17])[O-:18].[Cs+:19].[Cs+:20].[NH:1]1[CH2:2][CH2:3][C:4]2([CH2:5][CH2:6][c:7]3[cH:8][cH:9][cH:10][cH:11][c:12]32)[CH2:13][CH2:14]1.[O:32]=[CH:33][N:34]([CH3:35])[CH3:36].[OH2:31]>>[N:1]1([CH2:22][c:23]2[cH:24][cH:25][c:26]([CH2:29][OH:30])[cH:27][cH:28]2)[CH2:2][CH2:3][C:4]2([CH2:5][CH2:6][c:7]3[cH:8][cH:9][cH:10][cH:11][c:12]32)[CH2:13][CH2:14]1

Participants

Reactant 6

HCID 962Water

HCID 6228Dimethylformamide

HCID 19660Carbonate Ion

HCID 104967Cesium cation2×

HCID 103304344-(Bromomethyl)benzyl alcohol

HCID 156376162,3-Dihydrospiro(indene-1,4'-piperidine)

Product 1

HCID 67087241[4-(Spiro[indane-1,4'-piperidine]-1'-ylmethyl)phenyl]methanol

Sources & evidence

ORD record: ord-abb40064d86440ad85ff55b0047cb5cc
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (7/10)
DOI: 10.1039/C8SC04228D

Reaction notes

Loading…