Hydrochloric Acid → HCID 178418386, compound

HRID 1153

Reaction equation

HRID 1153 reaction equation
[O:1]=[C:2]([CH2:8][C:9](=[O:19])[C:10]1[C:15]([CH3:16])=[CH:14][C:13]([CH3:17])=[CH:12][C:11]=1[CH3:18])[C:3]([O:5][CH2:6][CH3:7])=[O:4].Cl.[N:21]([O-])=[O:22].[Na+]>C(O)C>[O:1]=[C:2]([C:8](=[N:21][OH:22])[C:9](=[O:19])[C:10]1[C:11]([CH3:18])=[CH:12][C:13]([CH3:17])=[CH:14][C:15]=1[CH3:16])[C:3]([O:5][CH2:6][CH3:7])=[O:4]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14945000Ethyl 2,4-dioxo-4-(2,4,6-trimethylphenyl)butanoateHCID 23668193Sodium Nitrite

Product 1

HCID 178418386HCID 178418386, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

N2O3 gas was slowly passed into a stirred solution of the product of step A (16.2 g) in 300 mL of ethanol until the disappearance of starting material was confirmed by TLC. N2O3 gas was generated by the dropwise addition of 12N aqueous HCl solution into an aqueous slurry of NaNO2. The solvent was removed from the mixture and 200 mL of water was added to the residue. The product was then extracted into ether. The ether extract was dried over Na2SO4 and evaporated to give 16.1 g of a semi-solid.

Workup

  1. customThe solvent was removed from the mixture and 200 mL of water
  2. additionwas added to the residue
  3. extractionThe product was then extracted into ether
  4. extractionThe ether extract
  5. dry with materialwas dried over Na2SO4
  6. customevaporated

Sources & evidence

ORD record
ord-d9ea025a9a0a4f688e80e240ea0b34ac
Source dataset
uspto-grants-1998_03
Patent number
US05723608

Linked notes

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