Eclazolast → 5-Chloro-N-(2-ethoxyethyl)-1,3-benzoxazole-2-carboxamide
Reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([C:10]([O:12]CCOCC)=O)=[N:7][C:6]=2[CH:18]=1.[CH2:19]([O:21][CH2:22][CH2:23][NH2:24])[CH3:20]>C1COCC1>[CH2:19]([O:21][CH2:22][CH2:23][NH:24][C:10]([C:8]1[O:9][C:5]2[CH:4]=[CH:3][C:2]([Cl:1])=[CH:18][C:6]=2[N:7]=1)=[O:12])[CH3:20]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of 2-ethoxyethyl 5-chlorobenzoxazol-2-carboxylate (10 g) and 3.5 g of ethoxyethylamine in 10 ml of THF was stirred at room temperature for 2 hours. The precipitated product was filtered and washed well with hexane to give 9 g of product; mp 110°-111° C.
Workup
- filtrationThe precipitated product was filtered
- washwashed well with hexane
Sources & evidence
- ORD record
- ord-e4ad9de29a11461c9ba5b669f4a581a9
- Source dataset
- uspto-grants-1984_12
- Patent number
- US04490373
Reaction notes
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