Pyridine, 2-(4-methoxyphenoxy)-5-(trifluoromethyl)- → 4-(5-Trifluoromethyl-pyridin-2-yloxy)-phenol

HRID 1155474

Reaction equation

HRID 1155474 reaction equation
C[O:2][C:3]1[CH:19]=[CH:18][C:6]([O:7][C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][N:9]=2)=[CH:5][CH:4]=1.Cl.N1C=CC=CC=1>O.Cl>[OH:2][C:3]1[CH:19]=[CH:18][C:6]([O:7][C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:15])[F:16])=[CH:10][N:9]=2)=[CH:5][CH:4]=1

Participants

5

Reactant 2

HCID 155242Pyridine, 2-(4-methoxyphenoxy)-5-(trifluoromethyl)-HCID 10176127Pyridinium chloride

Product 1

HCID 1552414-(5-Trifluoromethyl-pyridin-2-yloxy)-phenol

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 962WaterSolvent

Procedure

The product from (c) (1.7 g) and excess of pyridine hydrochloride were heated together for 8 hours at 180° C. The mixture was cooled, diluted with water and 2-molar hydrochloric acid, and extracted with ether. The extracts were dried and evaporated to yield an oil identified as the required hydroxy compound.

Workup

  1. temperatureThe mixture was cooled
  2. extractionextracted with ether
  3. customThe extracts were dried
  4. customevaporated
  5. customto yield an oil

Sources & evidence

ORD record
ord-b2b93f581afd4ba08de951bf7d3c848f
Source dataset
uspto-grants-1981_11
Patent number
US04302242

Linked notes

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