Diethyl Ether → 2,3-Dimethyl-2-aminobutyronitrile hydrochloride

HRID 1156229

Reaction equation

HRID 1156229 reaction equation
[C-:1]#[N:2].[K+].[CH3:4][CH:5]([CH3:9])[C:6](=O)[CH3:7].[Cl-:10].[NH4+:11].CCOCC>O>[ClH:10].[CH3:7][C:6]([NH2:11])([CH:5]([CH3:9])[CH3:4])[C:1]#[N:2]

Participants

6

Reactant 4

HCID 3283Diethyl EtherHCID 9032Potassium CyanideHCID 112513-Methyl-2-butanoneHCID 25517Ammonium Chloride

Product 1

HCID 129454442,3-Dimethyl-2-aminobutyronitrile hydrochloride

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The reactant 2,3-dimethyl-2-aminobutyronitrile hydrochloride was prepared by the following reaction. A solution of 136 grams (g) (2.1 moles) of potassium cyanide in 220 milliliters (ml) of water was added dropwise at 10°-15° C. to a mixture of 172.2 g (2.0 moles) of 3-methyl-2-butanone, 110.2 g (2.1 moles) ammonium chloride, and 300 ml of ether. The mixture was allowed to reach room temperature at which it was stirred overnight.

Workup

  1. customto reach room temperature at which it

Sources & evidence

ORD record
ord-51f7cd9ddd6e409594d72f31125435f6
Source dataset
uspto-grants-1982_06
Patent number
US04335053

Linked notes

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