Hydrogen Bromide → HCID 20519295, compound

HRID 1156288Notes

Reaction equation

HRID 1156288 reaction equation
Cl.Cl.[CH2:3]([N:7]1[CH2:12][CH2:11][N:10]([C:13]2[CH:18]=[CH:17][C:16]([O:19]C)=[CH:15][CH:14]=2)[CH2:9][CH2:8]1)[CH2:4][CH2:5][CH3:6].[BrH:21]>C(O)(=O)C>[BrH:21].[CH2:3]([N:7]1[CH2:12][CH2:11][N:10]([C:13]2[CH:14]=[CH:15][C:16]([OH:19])=[CH:17][CH:18]=2)[CH2:9][CH2:8]1)[CH2:4][CH2:5][CH3:6]

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 205193341-Butyl-4-(4-methoxyphenyl)piperazine dihydrochloride

Product 1

HCID 20519295HCID 20519295, compoundYield 81%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture of 12.5 parts of 1-butyl-4-(4-methoxyphenyl)piperazine dihydrochloride and 150 parts of hydrobromic acid solution 48% in glacial acetic acid is stirred and refluxed overnight. The reaction mixture is evaporated and the residue is triturated in 2-propanone. The product is filtered off and crystallized from water, yielding 13.1 parts (81%) of 4-(4-butyl-1-piperazinyl)phenol monohydrobromide; mp. 281.9° C.

Workup

  1. temperaturerefluxed overnight
  2. customThe reaction mixture is evaporated
  3. customthe residue is triturated in 2-propanone
  4. filtrationThe product is filtered off
  5. customcrystallized from water

Sources & evidence

ORD record
ord-1be21f24d8654bafaff93eb2bfda52dd
Source dataset
uspto-grants-1982_06
Patent number
US04335125

Reaction notes

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