Phosphorus oxide (P4O10) → HCID 12851823, compound
Reaction equation
[CH3:1][O:2][C:3]1[CH:20]=[CH:19][C:6]([C:7]([NH:9][CH2:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[CH3:18])=O)=[CH:5][CH:4]=1.P(Cl)(Cl)(Cl)=O.O=P12OP3(OP(OP(O3)(O1)=O)(=O)O2)=O>>[CH3:1][O:2][C:3]1[CH:20]=[CH:19][C:6]([C:7]2[C:17]3[C:12](=[C:13]([CH3:18])[CH:14]=[CH:15][CH:16]=3)[CH2:11][CH2:10][N:9]=2)=[CH:5][CH:4]=1Participants
4
Procedure
1-(4-Methoxybenzoylamino)-2-(2-methylphenyl)ethane, phosphorus oxychloride and phosphorus pentoxide were reacted in the same way as in step (b) of Example 1 to afford 1-(4-methoxyphenyl)-5-methyl-3,4-dihydroisoquinoline as colorless prisms having a melting point of 83.0° to 83.5° C.
Sources & evidence
- ORD record
- ord-067edc8b37f844ef9acaeb8805180b93
- Source dataset
- uspto-grants-1982_06