1-[4-(3-Phenylpropyl)piperidin-1-yl]octan-3-one → 6-{2-[4-(3-Phenylpropyl)piperidin-1-yl]ethyl}undecan-6-ol
Reaction equation
[CH2:1]([Mg]Br)[CH2:2][CH2:3][CH2:4][CH3:5].[C:8]1([CH2:14][CH2:15][CH2:16][CH:17]2[CH2:22][CH2:21][N:20]([CH2:23][CH2:24][C:25](=[O:31])[CH2:26][CH2:27][CH2:28][CH2:29][CH3:30])[CH2:19][CH2:18]2)[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>C1COCC1>[C:8]1([CH2:14][CH2:15][CH2:16][CH:17]2[CH2:18][CH2:19][N:20]([CH2:23][CH2:24][C:25]([OH:31])([CH2:1][CH2:2][CH2:3][CH2:4][CH3:5])[CH2:26][CH2:27][CH2:28][CH2:29][CH3:30])[CH2:21][CH2:22]2)[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
1 equivalent of pentylmagnesium bromide was reacted with 1 equivalent of the compound obtained in Example 2, in anhydrous THF, under nitrogen, at room temperature. The product thus obtained was worked up and purified on a column of silica. The results of the NMR and mass spectrometry analyses were in accordance with the expected structure.