Propylene Glycol → 1,1,1,3,3,3-Hexafluoro-2-propanol

HRID 1160441

Reaction equation

C(O)C(O)C.C1(C)CCC(C(C)C)C(O)C1.C(F)[O:18][CH:19]([C:24]([F:27])([F:26])[F:25])[C:20]([F:23])([F:22])[F:21]>>[CH:19]([OH:18])([C:24]([F:27])([F:26])[F:25])[C:20]([F:23])([F:22])[F:21]

Participants

Reactant 3

HCID 1030Propylene Glycol

HCID 1254Menthol

HCID 5206Sevoflurane

Product 1

HCID 135291,1,1,3,3,3-Hexafluoro-2-propanol

Procedure

Table 2 resumes the tests realized with the agents propylene glycol and menthol proposed for the stabilization of sevoflurane against the degradation by alumina and the results for total impurity and for the single impurity HFIP obtained with and without alumina after stress at 60° C. for 22 hours. The total impurity is the sum of the ratio between the area for each impurity and the area of the internal standard (toluene) and HFIP is the ratio between the area of HFIP and the area of toluene obtained in the chromatograms.

Sources & evidence

ORD record: ord-177e0a2589fe43c586745e7dff6de1e8
Source dataset: uspto-grants-2010_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07816409B2

Linked notes

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