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Hydrochloric Acid → 2-Ethylsulfonyl-6-n-propylimidazo[1,2-b]pyridazin-3-ylsulfonamide

HRID 1160761
Notes
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Reaction equation

HRID 1160761 reaction equation
[CH2:1]([S:3][C:4]1[N:5]=[C:6]2[CH:11]=[CH:10][C:9]([CH2:12][CH2:13][CH3:14])=[N:8][N:7]2[C:15]=1[S:16]([NH2:19])(=[O:18])=[O:17])[CH3:2].C([O-])([O-])=[O:21].C([O-])([O-])=O.OO.OO.OO.[Na+].[Na+].[Na+].[Na+].Cl.[OH2:39]>C(#N)C>[CH2:1]([S:3]([C:4]1[N:5]=[C:6]2[CH:11]=[CH:10][C:9]([CH2:12][CH2:13][CH3:14])=[N:8][N:7]2[C:15]=1[S:16]([NH2:19])(=[O:17])=[O:18])(=[O:21])=[O:39])[CH3:2]
ParticipantsConditionsProcedureWorkupSources & evidenceReaction notes

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962Water2×HCID 159762Sodium percarbonateHCID 230281222-Ethylthio-6-n-propylimidazo[1,2-b]pyridazin-3-ylsulfonamide

Product 1

HCID 230281332-Ethylsulfonyl-6-n-propylimidazo[1,2-b]pyridazin-3-ylsulfonamide

Reagents, catalysts & solvents 1

HCID 6342
Acetonitrile
Solvent

Conditions

Temperature
55 °C

Procedure

2-Ethylthio-6-n-propylimidazo[1,2-b]pyridazin-3-ylsulfonamide (0.30 g, 1.00 mmol) was suspended in acetonitrile (1.0 ml) and water (4.0 ml), and sodium percarbonate (effective oxygen concentration, 12.2%; 0.33 g; 2.50 mmol) was added thereto at 45° C. and stirred at 50 to 60° C. for 2.5 hours. The reaction mixture was poured into water and acidified with dilute hydrochloric acid, and the precipitated insoluble solids were collected by filtration and washed with water, to give the title compound as white crystals. The yield was 0.25 g (75.3%).

Workup

  1. filtrationthe precipitated insoluble solids were collected by filtration
  2. washwashed with water

Sources & evidence

ORD record
ord-a9aac78e05304edbab31ed6d61e29c55
Source dataset
uspto-grants-2010_10
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US07816526B2

Reaction notes

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On this pageParticipantsConditionsProcedureWorkupSources & evidenceReaction notes