Glyoxylic Acid → HCID 178521512, compound

HRID 1164732

Reaction equation

HRID 1164732 reaction equation
[C:1]([OH:5])(=O)[CH:2]=[O:3].Cl.[Cl:7][C:8]1[CH:13]=[C:12]([Cl:14])[CH:11]=[CH:10][C:9]=1[NH:15][NH2:16]>Cl.O>[Cl:7][C:8]1[CH:13]=[C:12]([Cl:14])[CH:11]=[CH:10][C:9]=1[NH:15][N:16]=[C:1]([OH:5])[CH:2]=[O:3]

Participants

5

Reactant 2

HCID 760Glyoxylic AcidHCID 2723905(2,4-Dichlorophenyl)hydrazine monohydrochloride

Product 1

HCID 178521512HCID 178521512, compoundYield 69%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 962WaterSolvent2×

Procedure

In a manner similar to that disclosed by HO House, et al (Organic Synthesis, Vol V, 258-263) the reaction of 3.4 g (0.046 mole) of glyoxylic acid in 40 mL of 2.5 N hydrochloric acid and 60 mL of water with a solution of 9.8 g (0.046 mole) of 2,4-dichlorophenylhydrazine hydrochloride in 30 mL of water produced 7.4 g of 2-oxoacetic acid 2,4-dichlorophenylhydrazone as a solid (m.p. 160° C., dec.).

Workup

  1. customIn a manner similar to that disclosed by HO House, et al (Organic Synthesis, Vol V, 258-263)

Sources & evidence

ORD record
ord-bdaffcab6cc541bbbd16baa0b1ae320b
Source dataset
uspto-grants-1990_03
Patent number
US04906287

Linked notes

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