Pyrazole → 3-fluoro-4-(1H-1,2,4-triazol-1-yl)benzaldehyde

HRID 1166084

Reaction equation

[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1F)[CH:5]=[O:6].[NH:11]1[CH:15]=[N:14][CH:13]=[N:12]1.FC1C=CC(C=O)=CC=1OC.N1C=CC=N1>>[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[N:11]1[CH:15]=[N:14][CH:13]=[N:12]1)[CH:5]=[O:6]

Participants

Reactant 4

HCID 1048Pyrazole

HCID 92571H-1,2,4-Triazole

HCID 5880883,4-Difluorobenzaldehyde

HCID 27373584-Fluoro-3-methoxybenzaldehyde

Product 1

HCID 162279523-fluoro-4-(1H-1,2,4-triazol-1-yl)benzaldehyde

Procedure

The title compound was prepared by a procedure analogous to Reference Example 5 by substituting 3,4-difluorobenzaldehyde and 1,2,4-triazole, respectively, for the 4-fluoro-3-methoxybenzaldehyde and pyrazole of Reference Example 5. MS 192 (M+H)+.

Sources & evidence

ORD record: ord-78f817196b97433d93c02f36b0169d04
Source dataset: uspto-grants-2003_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06613747B2

Linked notes

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