Ammonia → 5-Chloro-2-methoxybenzene-1-sulfonamide
Reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:12][CH3:13])=[C:6]([S:8](Cl)(=[O:10])=[O:9])[CH:7]=1.[NH3:14]>O1CCCC1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:12][CH3:13])=[C:6]([S:8]([NH2:14])(=[O:10])=[O:9])[CH:7]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution of 5-chloro-2-methoxybenzene sulfonyl chloride (1.0 g, 4.15 mmol) in tetrahydrofuran (10 mL) was bubbled ammonia gas until saturated. The reaction was stirred overnight. The white solid that precipitated out of solution was collected by filtration and washed with dichloromethane to give the title compound (0.52 g).
Workup
- customThe white solid that precipitated out of solution
- filtrationwas collected by filtration
- washwashed with dichloromethane
Sources & evidence
- ORD record
- ord-f40b87c7e96a4cb98fe793f02a60727f
- Source dataset
- uspto-grants-2006_08
- Patent number
- US07098212B2
Reaction notes
Loading…