N-(Piperidin-4-yl)-4'-(trifluoromethyl)-biphenyl-2-carboxamide → Isopropyl 2-ethyl-2-phenyl-5-{4-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-piperidin-1-yl}-pentanecarboxylate

HRID 1167103

Reaction equation

HRID 1167103 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([NH:7][C:8]([C:10]2[C:11]([C:16]3[CH:21]=[CH:20][C:19]([C:22]([F:25])([F:24])[F:23])=[CH:18][CH:17]=3)=[CH:12][CH:13]=[CH:14][CH:15]=2)=[O:9])[CH2:3][CH2:2]1.Br[CH2:27][CH2:28][CH2:29][C:30]([CH2:44][CH3:45])([C:38]1[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=1)[CH2:31][C:32]([O:34][CH:35]([CH3:37])[CH3:36])=[O:33]>>[CH2:44]([C:30]([C:38]1[CH:39]=[CH:40][CH:41]=[CH:42][CH:43]=1)([CH2:29][CH2:28][CH2:27][N:1]1[CH2:6][CH2:5][CH:4]([NH:7][C:8]([C:10]2[C:11]([C:16]3[CH:17]=[CH:18][C:19]([C:22]([F:23])([F:24])[F:25])=[CH:20][CH:21]=3)=[CH:12][CH:13]=[CH:14][CH:15]=2)=[O:9])[CH2:3][CH2:2]1)[CH2:31][C:32]([O:34][CH:35]([CH3:36])[CH3:37])=[O:33])[CH3:45]

Participants

3

Reactant 2

HCID 9928271N-(Piperidin-4-yl)-4'-(trifluoromethyl)-biphenyl-2-carboxamideHCID 22995704Isopropyl 5-bromo-2-ethyl-2-phenyl-pentanecarboxylate

Product 1

HCID 22995748Isopropyl 2-ethyl-2-phenyl-5-{4-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-piperidin-1-yl}-pentanecarboxylate

Procedure

Prepared from 4′-trifluoromethyl-biphenyl-2-carboxylic acid-piperidin-4-ylamide and isopropyl 5-bromo-2-ethyl-2-phenyl-pentanecarboxylate.

Sources & evidence

ORD record
ord-78bf5f5b417f4c6db993cdf3cdad9f7f
Source dataset
uspto-grants-2003_09
Patent number
US06617325B1

Linked notes

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