Isopropanol → 2-Methoxycyclohexanone
Reaction equation
CC[C@@H]1[C@@H]2C[C@@H]([C@H](O)C3[C:21]4[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=4)N=CC=3)N(CC2)C1.[OH-:23].[Na+].[CH:25]([OH:28])(C)C>C[N+](C)(C)C.[Cl-]>[CH3:25][O:28][CH:16]1[CH2:17][CH2:18][CH2:19][CH2:20][C:21]1=[O:23]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
Example 1 is repeated, except that isopropanol is used as solvent, 10 mg of hydrocinchonidine are used as modifier and 100 mg of catalyst are used. In addition, 800 mg of Amberlite IRA-900 (strongly basic anion exchanger, activated using NaOH) are added. The yield is 0.36 g of product of 95% purity containing 5% solvent (44%).
Workup
- additionare added
Sources & evidence
- ORD record
- ord-61d0b03ba9bd4e2c877b06e3ba56c223
- Source dataset
- uspto-grants-2003_09
- Patent number
- US06617475B2
Reaction notes
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