Diphosgene → 4-Chloro-2,6-difluorophenyl Isocyanate
Reaction equation
[Cl:1][C:2]1[CH:8]=[C:7]([F:9])[C:5]([NH2:6])=[C:4]([F:10])[CH:3]=1.Cl[C:12](OC(Cl)(Cl)Cl)=[O:13]>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:8]=[C:7]([F:9])[C:5]([N:6]=[C:12]=[O:13])=[C:4]([F:10])[CH:3]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
40 g of 4-chloro-2,6-difluoroaniline were dissolved in 300 ml of absolute toluene. With stirring, 100 ml of trichloromethyl chloroformate were added dropwise at 20° C. The mixture was slowly heated to reflux. After three and half hours, the mixture was concentrated and the resulting isocyanate was used directly for the synthesis of intermediate 3.
Workup
- temperatureThe mixture was slowly heated to reflux
- concentrationAfter three and half hours, the mixture was concentrated
- customthe resulting isocyanate was used directly for the synthesis of intermediate 3
Sources & evidence
- ORD record
- ord-c72dc09e23a840ff98fb812ba2fd6007
- Source dataset
- uspto-grants-2003_09
- Patent number
- US06624119B1
Reaction notes
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