N-(2-Aminoethyl)piperidine → (2-Chloro-5-(2-thienyl)pyrimidine-4-yl)-(2-piperidin-1-yl-ethyl)-amine

Reaction equation

[Cl:1][C:2]1[N:7]=[C:6](Cl)[C:5](I)=[CH:4][N:3]=1.[N:10]1([CH2:16][CH2:17][NH2:18])[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1.CC1(C)C(C)(C)OB([C:27]2[S:28][CH:29]=[CH:30][CH:31]=2)O1>>[Cl:1][C:2]1[N:7]=[C:6]([NH:18][CH2:17][CH2:16][N:10]2[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]2)[C:5]([C:27]2[S:28][CH:29]=[CH:30][CH:31]=2)=[CH:4][N:3]=1

Participants

Reactant 3

HCID 33944N-(2-Aminoethyl)piperidine

HCID 2634382,4-Dichloro-5-iodopyrimidine

HCID 107036284,4,5,5-Tetramethyl-2-(thiophen-2-yl)-1,3,2-dioxaborolane

Product 1

HCID 58985779(2-Chloro-5-(2-thienyl)pyrimidine-4-yl)-(2-piperidin-1-yl-ethyl)-amine

Procedure

Preparation according to procedures 2 and 3 with the use of 2,4-dichloro-5-iodopyrimidine, 2-piperidin-1-yl-ethylamine and 4,4,5,5-tetramethyl-2-(2-thienyl)-1,3,2-dioxaborolane.

Workup

customPreparation

Sources & evidence

ORD record: ord-30d797e7a27547f0a1c39915fb2d53f9
Source dataset: uspto-grants-2010_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07825128B2

Reaction notes

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