Octanoyl chloride → HCID 178442555, compound
Reaction equation
[C:1](Cl)(=O)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].[CH3:11][NH:12][C:13](=[S:16])[NH:14][NH2:15].[OH-].[K+]>O1CCCC1>[CH2:2]([C:1]1[N:12]([CH3:11])[C:13]([SH:16])=[N:14][N:15]=1)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
5 g (30.74 mmol, 1 eq) of octanoyl chloride and 3.58 g (33.81 mmol, 1.1 eq) of 4-methyl-3-thiosemicarbazide in solution in 350 ml of tetrahydrofuran are stirred for 3 hours at room temperature. The solution is concentrated to dryness. The solid obtained is taken up in 350 ml of a 10% aqueous potassium hydroxide solution 35 g (0.82 mmol, 20 eq). The reaction mixture is stirred overnight under reflux. In the cold state, the reaction medium is acidified. The precipitate obtained is filtered, washed with a minimum of water and then dried. 5.94 g (90%) of the expected compound are obtained.