1,4-Dioxane → Hydrochloric Acid

HRID 117307

Reaction equation

HRID 117307 reaction equation
[CH2:28]1[O:29][CH2:30][CH2:31][O:32][CH2:33]1.[CH3:1][N:2]([c:3]1[n:4][c:5]([NH2:9])[cH:6][cH:7][cH:8]1)[CH:10]1[CH2:11][CH2:12][N:13]([CH3:16])[CH2:14][CH2:15]1.[F:17][c:18]1[c:19]([C:20](=[O:21])[Cl:22])[c:23]([F:27])[cH:24][cH:25][cH:26]1>>[CH3:1][N:2]([c:3]1[n:4][c:5]([NH:9][C:20]([c:19]2[c:18]([F:17])[cH:26][cH:25][cH:24][c:23]2[F:27])=[O:21])[cH:6][cH:7][cH:8]1)[CH:10]1[CH2:11][CH2:12][N:13]([CH3:16])[CH2:14][CH2:15]1.[ClH:22]

Participants

5

Reactant 3

HCID 312751,4-DioxaneHCID 874382,6-Difluorobenzoyl chlorideHCID 58997271N-methyl N-(1-methyl-piperidin-4-yl)-pyridine-2,6-diamine

Product 2

HCID 313Hydrochloric AcidHCID 589973692,6-difluoro-N-[6-[methyl-(1-methylpiperidin-4-yl)amino]-2-pyridinyl]benzamide

Sources & evidence

ORD record
ord-2f23e2faf48448aa810f49ad61b065b6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Linked notes

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