tert-butyl 3-methyl-N-(methylsulfonyl)-L-valinate → (S)-3,3-Dimethyl-2-(methylsulfonamido)butanoic acid
Reaction equation
[CH3:1][C:2]([CH3:17])([CH3:16])[C@@H:3]([C:9]([O:11]C(C)(C)C)=[O:10])[NH:4][S:5]([CH3:8])(=[O:7])=[O:6]>Cl.O1CCOCC1>[CH3:1][C:2]([CH3:17])([CH3:16])[C@@H:3]([C:9]([OH:11])=[O:10])[NH:4][S:5]([CH3:8])(=[O:7])=[O:6]Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
A solution of Example 152A (59 mg, 0.22 mmol) in 4N HCl in dioxane (1 mL) at 25° C. for 4 h, and the solvents were evaporated to give the crude title compound (49 mg, 100%).
Workup
- customthe solvents were evaporated
Sources & evidence
- ORD record
- ord-b2894561c7914198ba750d8652d40cbb
- Source dataset
- uspto-grants-2010_11
- Patent number
- US07834043B2
Reaction notes
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