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tert-butyl N-(2-{[(benzyloxy)carbonyl]amino}ethyl)-3-methyl-L-valinate → HCID 67405688, compound

HRID 1174404
Notes
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Reaction equation

HRID 1174404 reaction equation
[CH2:1]([O:8][C:9]([NH:11][CH2:12][CH2:13][NH:14][C@H:15]([C:20]([O:22]C(C)(C)C)=[O:21])[C:16]([CH3:19])([CH3:18])[CH3:17])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>Cl.O1CCOCC1>[CH2:1]([O:8][C:9]([NH:11][CH2:12][CH2:13][NH:14][C@H:15]([C:20]([OH:22])=[O:21])[C:16]([CH3:19])([CH3:17])[CH3:18])=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

4

Reactant 1

HCID 67407977tert-butyl N-(2-{[(benzyloxy)carbonyl]amino}ethyl)-3-methyl-L-valinate

Product 1

HCID 67405688HCID 67405688, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

The product from Example 180A (0.870 mmol) was dissolved in an HCl solution in dioxane (5.0 mL, 4 N), and the mixture was stirred at room temperature for 12 hours. The solvent was evaporated to afford the title compound as the hydrochloride salt. The residue was used without further purification.

Workup

  1. customThe solvent was evaporated

Sources & evidence

ORD record
ord-a7b90aa7d1a0457587b3c65ab332ad53
Source dataset
uspto-grants-2010_11
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US07834043B2

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes