Hydroxylamine → HCID 74313832, compound
Reaction equation
[CH2:1]([O:3][CH2:4][CH2:5][O:6][CH2:7][CH2:8][C:9]#[N:10])[CH3:2].[NH2:11][OH:12]>CCO>[CH2:1]([O:3][CH2:4][CH2:5][O:6][CH2:7][CH2:8][C:9](=[N:11][OH:12])[NH2:10])[CH3:2]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of 3-(2-ethoxyethoxy)propanenitrile (1 g, 7 mmol) and NH2OH (50% in water, 0.64 cm3, 10.5 mmol) in EtOH (10 cm3) were heated to reflux for 24 hours, after which the solvent and excess hydroxylamine were removed by rotary evaporator. The residue was freeze-dried and kept in high vacuum line for several hours to give 3(2-ethoxyethoxy)N′-hydroxypropanimidamide (1.2 g, 97.6%) as a colourless oil.
Workup
- temperatureto reflux for 24 hours
- customafter which the solvent and excess hydroxylamine were removed by rotary evaporator
- customThe residue was freeze-dried
- waitkept in high vacuum line for several hours
Sources & evidence
- ORD record
- ord-508e449c014c421f810c600e752c410f
- Source dataset
- uspto-grants-2010_11
- Patent number
- US07838483B2
Reaction notes
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