Cesium carbonate → 2-[[2-[[(2,3-difluorophenyl)methyl]thio]-6-[(2-thiazolylsulfonyl)amino]-4-pyrimidinyl]oxy]-(2R)-propanoic acid ethyl ester

Reaction equation

[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[S:6]([NH2:9])(=[O:8])=[O:7].C1(P(C2CCCCC2)C2C=CC=CC=2C2C(C(C)C)=CC(C(C)C)=CC=2C(C)C)CCCCC1.C(=O)([O-])[O-].[Cs+].[Cs+].[CH2:50]([O:52][C:53](=[O:74])[C@H:54]([O:56][C:57]1[CH:62]=[C:61](Cl)[N:60]=[C:59]([S:64][CH2:65][C:66]2[CH:71]=[CH:70][CH:69]=[C:68]([F:72])[C:67]=2[F:73])[N:58]=1)[CH3:55])[CH3:51]>O1CCOCC1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd].[Pd]>[CH2:50]([O:52][C:53](=[O:74])[C@H:54]([O:56][C:57]1[CH:62]=[C:61]([NH:9][S:6]([C:2]2[S:1][CH:5]=[CH:4][N:3]=2)(=[O:8])=[O:7])[N:60]=[C:59]([S:64][CH2:65][C:66]2[CH:71]=[CH:70][CH:69]=[C:68]([F:72])[C:67]=2[F:73])[N:58]=1)[CH3:55])[CH3:51]