Benzyl isocyanate → HCID 178418694, compound

HRID 11756

Reaction equation

HRID 11756 reaction equation
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[N:11]=[C:10]([NH2:12])[NH:9][C:8]2=[N:13][CH:14]=[CH:15][C:7]=12.[CH2:16]([N:23]=[C:24]=[O:25])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>C1COCC1>[CH2:16]([NH:23][C:24]([NH:12][C:10]1[NH:9][C:8]2=[N:13][CH:14]=[CH:15][C:7]2=[C:6]([C:2]2[O:1][CH:5]=[CH:4][CH:3]=2)[N:11]=1)=[O:25])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Participants

4

Reactant 2

HCID 76639Benzyl isocyanateHCID 178419058HCID 178419058, compound

Product 1

HCID 178418694HCID 178418694, compoundYield 19.1%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 4-(2-furyl)-1H-pyrrolo[2,3-d]pyrimidine-2-amine (192 mg, 0.96 mmol) in THF (3 mL) was treated with benzyl isocyanate (118 μL, 0.96 mmol), stirred at room temperature for 16 h and the resulting solid filtered and washed with EtOAc to give the title compound (61 mg, 19%) as a yellow solid.

Workup

  1. filtrationthe resulting solid filtered
  2. washwashed with EtOAc

Sources & evidence

ORD record
ord-e3a6e51d909246489019c19083530959
Source dataset
uspto-grants-2006_08
Patent number
US07098333B2

Linked notes

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