Isobutyryl chloride → N-(2-bromo-5-methylphenyl)-2-methylpropanamide

HRID 1176310

Reaction equation

[Br:1][C:2]1[CH:8]=[CH:7][C:6]([CH3:9])=[CH:5][C:3]=1[NH2:4].[C:10](Cl)(=[O:14])[CH:11]([CH3:13])[CH3:12]>>[Br:1][C:2]1[CH:8]=[CH:7][C:6]([CH3:9])=[CH:5][C:3]=1[NH:4][C:10](=[O:14])[CH:11]([CH3:13])[CH3:12]

Participants

Reactant 2

HCID 62325Isobutyryl chloride

HCID 64220652-Bromo-5-methylaniline

Product 1

HCID 68542723N-(2-bromo-5-methylphenyl)-2-methylpropanamide

Procedure

Analogously to Example 18e, 12.20 g of 2-bromo-5-methylaniline are reacted with 7.77 ml of isobutyryl chloride. The title compound is obtained as a white solid. Rt=4.29.

Sources & evidence

ORD record: ord-94c32fa79a6b49a99ed0adb9db420cd0
Source dataset: uspto-grants-2010_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07842688B2

Linked notes

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