1,3-Dibromopropane → 1-(3-Bromopropoxy)-2,3-difluorobenzene
Reaction equation
[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[CH:4][C:3]=1[OH:9].[Br:10][CH2:11][CH2:12][CH2:13]Br>>[Br:10][CH2:11][CH2:12][CH2:13][O:9][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]([F:8])[C:2]=1[F:1]Participants
3
Procedure
Analogously to Example 91b, 2.00 g of 2,3-difluorophenol and 30.7 g of 1,3-dibromopropane are reacted. The title compound is obtained as a colourless oil. Rf=0.39 (1:10 EtOAc-heptane); Rt=4.82.
Sources & evidence
- ORD record
- ord-f21dc44859e641d1b096712f54018cdf
- Source dataset
- uspto-grants-2010_11
- Patent number
- US07842688B2
Reaction notes
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