Dimethylformamide → 4,4'-Dicyanobenzil
Reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:10]([C:12]2[CH:17]=[CH:16][C:15](Br)=[CH:14][CH:13]=2)=[O:11])=[O:9])=[CH:4][CH:3]=1.[Cu](C#N)[C:20]#[N:21].[CH3:24][N:25](C=O)C>>[C:20]([C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:10]([C:12]2[CH:17]=[CH:16][C:15]([C:24]#[N:25])=[CH:14][CH:13]=2)=[O:11])=[O:9])=[CH:4][CH:3]=1)#[N:21]Participants
4
Procedure
Here we have discovered that the compound can be easily synthesized from commercially available 4,4′-dibromobenzil. The reaction between 4,4′-dibromobenzil and copper cyanide in DMF at 165° C. yielded 4,4′-dicyanobenzil (JYC-I-097-A) as a yellow solid (1.36 g, 48%) after column chromatography. The scheme of the reaction is shown in FIG. 12.
Sources & evidence
- ORD record