Hydrogen Bromide → 1-(Bromomethyl)-2-(trifluoromethyl)benzene

HRID 1178015

Reaction equation

HRID 1178015 reaction equation
[F:1][C:2]([F:12])([F:11])[C:3]1[CH:10]=[CH:9][CH:8]=[CH:7][C:4]=1[CH2:5]O.[BrH:13]>O>[F:1][C:2]([F:12])([F:11])[C:3]1[CH:10]=[CH:9][CH:8]=[CH:7][C:4]=1[CH2:5][Br:13]

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 676662-(Trifluoromethyl)benzylic alcohol

Product 1

HCID 1230571-(Bromomethyl)-2-(trifluoromethyl)benzene

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 2-trifluoromethyl benzyl alcohol (1 g, 5.67 mmol) in aqueous HBr (6 mL) was stirred at 50° C. for 4 hrs. The reaction mixture was diluted with cold water and the product extracted with ethyl acetate. The organic layer was washed with saturated brine solution, dried over sodium sulphate and concentrated to afford 780 mg of 2-trifluoromethylbenzyl bromide.

Workup

  1. extractionthe product extracted with ethyl acetate
  2. washThe organic layer was washed with saturated brine solution
  3. dry with materialdried over sodium sulphate
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-de488eae72364be98e4a6cd3d7e791fe
Source dataset
uspto-grants-2010_11
Patent number
US07842696B2

Linked notes

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