Lithium Hydroxide → 5-Phenyl-[1,3,4]oxadiazole-2-carboxylic acid lithium salt
Reaction equation
[Li+:1].[OH-].C([O:5][C:6]([C:8]1[O:9][C:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[N:11][N:12]=1)=[O:7])C>C1COCC1.CO.O>[Li+:1].[C:13]1([C:10]2[O:9][C:8]([C:6]([O-:7])=[O:5])=[N:12][N:11]=2)[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
LiOH (25 mg, 0.60 mmol) was added at room temperature to a stirred solution of 5-phenyl-[1,3,4]oxadiazole-2-carboxylic acid ethyl ester (60 mg, 0.275 mmol) in THF:MeOH:H2O (3:1:1, 5 mL) and the resulting mixture stirred for 1 hr. Removal of the volatiles by evaporation under reduced pressure afforded 5-phenyl-[1,3,4]oxadiazole-2-carboxylic acid lithium salt, which was used for the next step without further purification.