Hydrazine hydrate (1:1) → (7-Methylthieno[3,2-d]pyrimidin-4-yl)hydrazine hydrochloride
Reaction equation
[Cl:1][C:2]1[C:3]2[S:10][CH:9]=[C:8]([CH3:11])[C:4]=2[N:5]=[CH:6][N:7]=1.O.[NH2:13][NH2:14]>C(O)C>[ClH:1].[CH3:11][C:8]1[C:4]2[N:5]=[CH:6][N:7]=[C:2]([NH:13][NH2:14])[C:3]=2[S:10][CH:9]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A suspension of 4-chloro-7-methylthieno[3,2-d]pyrimidine (4, 3.1 g, 17 mmol) and hydrazine monohydrate (3.5 mL, 72 mmol) in ethanol (34 mL) was heated at reflux for 1 hour. After cooling to room temperature, the solid product was collected by vacuum filtration to give (7-methylthieno[3,2-d]pyrimidin-4-yl)hydrazine hydrochloride (3.2 g, 88% yield) as a white solid.
Workup
- temperaturewas heated
- temperatureat reflux for 1 hour
- filtrationthe solid product was collected by vacuum filtration
Sources & evidence
- ORD record
- ord-39a22508340f48f6a4f3eb4aa3f801b3
- Source dataset
- uspto-grants-2007_10
- Patent number
- US07285556B2
Reaction notes
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