Hydrazine hydrate (1:1) → 6-hydrazino-1-isobutyl-3-methyl-2,4(1H,3H)-pyrimidinedione

HRID 1181674Notes

Reaction equation

HRID 1181674 reaction equation
O.[NH2:2][NH2:3].Cl[C:5]1[N:10]([CH2:11][CH:12]([CH3:14])[CH3:13])[C:9](=[O:15])[N:8]([CH3:16])[C:7](=[O:17])[CH:6]=1>C(O)C>[NH:2]([C:5]1[N:10]([CH2:11][CH:12]([CH3:14])[CH3:13])[C:9](=[O:15])[N:8]([CH3:16])[C:7](=[O:17])[CH:6]=1)[NH2:3]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 52825666-Chloro-1-isobutyl-3-methylpyrimidine-2,4(1H,3H)-dione

Product 1

HCID 193560846-hydrazino-1-isobutyl-3-methyl-2,4(1H,3H)-pyrimidinedione

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Hydrazine hydrate (6.5 ml) was added to a solution of 6-Chloro-1-isobutyl-3-methylpyrmidine-2,4(1H,3H)-dione (10 g) in ethanol (40 ml). The mixture was heated at reflux for 5 hours, cooled to room temperature and then evaporated under reduced pressure. The residue was crystallized from ethanol to give the subtitle compound (6.7 g). Mass: 213.00 (M+H).

Workup

  1. temperatureThe mixture was heated
  2. temperatureat reflux for 5 hours
  3. customevaporated under reduced pressure
  4. customThe residue was crystallized from ethanol

Sources & evidence

ORD record
ord-954b8ba40dbb4a7b823257ee4864e24b
Source dataset
uspto-grants-2007_10
Patent number
US07285558B2

Reaction notes

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