Hydrazine hydrate (1:1) → 6-hydrazino-1-isobutylpyrimidine-2,4(1H,3H)-dione
Reaction equation
O.[NH2:2][NH2:3].Cl[C:5]1[N:10]([CH2:11][CH:12]([CH3:14])[CH3:13])[C:9](=[O:15])[NH:8][C:7](=[O:16])[CH:6]=1>C(O)C>[NH:2]([C:5]1[N:10]([CH2:11][CH:12]([CH3:14])[CH3:13])[C:9](=[O:15])[NH:8][C:7](=[O:16])[CH:6]=1)[NH2:3]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Hydrazine hydrate (5.9 ml) was added to a solution of 6-chloro-1-isobutylpyrimidine-2,4(1H,3H)-dione synthesized according to procedure described in Heterocycles, 1990, 31(9), 1641-1646, (5.9 g) in ethanol (100 ml). The mixture was heated at reflux for 16 hours, cooled to room temperature and then evaporated under reduced pressure. The residue was crystallized from ethanol to give the subtitle compound (5.8 g).
Workup
- customsynthesized
- temperatureThe mixture was heated
- temperatureat reflux for 16 hours
- customevaporated under reduced pressure
- customThe residue was crystallized from ethanol
Sources & evidence
- ORD record
- ord-1f7001115b7e4bd986db5fa5ead6b051
- Source dataset
- uspto-grants-2007_10
- Patent number
- US07285558B2
Reaction notes
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