HCID 67434840, compound → 4-Phenoxynicotinaldehyde
Reaction equation
[O:1]([C:8]1[CH:13]=[CH:12][N:11]=[CH:10][C:9]=1[CH2:14][OH:15])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C1COCC1.O=[Mn]=O>[O:1]([C:8]1[C:9]([CH:14]=[O:15])=[CH:10][N:11]=[CH:12][CH:13]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
MnO2 (289 mg, 3.33 mmol) was added to a solution of (4-phenoxypyridin-3-yl)methanol (70 mg, 0.33 mmol) in THF (10 mL). After stiffing overnight the reaction mixture was filtered (celite). Removal of the solvent provided 4-phenoxynicotinaldehyde (70 mg, 95%). MS [M+H]+=200.1.
Workup
- filtrationthe reaction mixture was filtered (celite)
- customRemoval of the solvent
Sources & evidence
- ORD record
- ord-0c8694d605674cafa346d891f12287e9
- Source dataset
- uspto-grants-2014_03
- Patent number
- US08664214B2
Reaction notes
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