S(=O)(=O)(O)O.Cl.[F:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[NH:14][NH2:15].[C:16](O)(=[O:23])[CH2:17][C:18]([C:20]([OH:22])=[O:21])=O>O>[F:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[N:14]1[C:16]([OH:23])=[CH:17][C:18]([C:20]([OH:22])=[O:21])=[N:15]1Sulfuric acid (400 ml) was added slowly to water (400 ml). After cooling to 5° C., 2-fluoro-phenylhydrazine hydrochloride (123 g, 757 mmol) was added resulting in a brown suspension. Then a solution of oxalacetic acid (100 g, 757 mmol) in water (400 ml) was added slowly during a period of 25 min. After 2 h the conversion was complete and the solid was filtered. After washing with water the solid was dried. The product was obtained as light brown solid (151 g, 90%).
Loading…
