1,3-Dibromopropane → Ethyl 1-pyridin-3-ylcyclobutane-1-carboxylate

HRID 1187387

Reaction equation

HRID 1187387 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH:2]=1.Br[CH2:14][CH2:15][CH2:16]Br>>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2([C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH2:16][CH2:15][CH2:14]2)[CH:2]=1

Participants

3

Reactant 2

HCID 80011,3-DibromopropaneHCID 96490Ethyl 3-pyridylacetate

Product 1

HCID 67246748Ethyl 1-pyridin-3-ylcyclobutane-1-carboxylate

Procedure

Prepared in a similar manner to that described above by reacting ethyl 2-pyridin-3-ylacetate with 1,3-dibromopropane to give ethyl 1-pyridin-3-ylcyclobutane-1-carboxylate which was then hydrogenated to give the desired compound as a brown oil (quantitative reaction).

Workup

  1. customPrepared in a similar manner to that

Sources & evidence

ORD record
ord-8ad4b7b25a8948c6b16f1d5fb5c1c881
Source dataset
uspto-grants-2014_03
Patent number
US08673938B2

Linked notes

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