Citric Acid → HCID 67566730, compound

HRID 1191970Notes

Reaction equation

HRID 1191970 reaction equation
[Na:1].[CH3:2][CH2:3][CH2:4][N:5]([C:9]([CH:11]([NH:17][C:18]([C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1)=[O:19])[CH2:12][CH2:13][C:14]([OH:16])=[O:15])=[O:10])[CH2:6][CH2:7][CH3:8].C(CN)O.C(O)(=O)CC(CC(O)=O)(C(O)=O)O>O>[Na:1].[CH3:2][CH2:3][CH2:4][N:5]([C:9]([CH:11]([NH:17][C:18]([C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1)=[O:19])[CH2:12][CH2:13][C:14]([OH:16])=[O:15])=[O:10])[CH2:6][CH2:7][CH3:8]

Participants

6

Reactant 4

HCID 311Citric AcidHCID 700EthanolamineHCID 4922ProglumideHCID 5360545Sodium

Product 1

HCID 67566730HCID 67566730, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

In another embodiment, a composition for IV injection can be made as follows: add 4263 g of the sodium salt of proglumide to 15 L of water and 93 g of ethanolamine and stir until a clear solution is obtained. After buffering with citric acid, the solution is diluted to a volume of 30 L, then filtered under pressure in an inert gas into 40,000 glass vials which are sterilized under heat, yielding 40,000 vials each containing 106.6 mg sodium proglumide, equivalent to 100 mg proglumide.

Workup

  1. customis obtained
  2. additionthe solution is diluted to a volume of 30 L
  3. filtrationfiltered under pressure in an inert gas into 40,000 glass vials which
  4. temperatureunder heat

Sources & evidence

ORD record
ord-ee737652bf5048daa246a908955b71cd
Source dataset
uspto-grants-2014_03
Patent number
US08680145B1

Reaction notes

Loading…