Di-tert-butyl azodicarboxylate → 4-{2-[2-(4-Chloro-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-2-cyclohexyl-ethoxy}-3-fluoro-benzonitrile

HRID 119204

Reaction equation

HRID 119204 reaction equation
[Cl:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[n:9][c:10]3[c:11]([n:12]2[CH:13]([CH2:14][OH:15])[CH:16]2[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21]2)[cH:22][c:23]([F:27])[c:24]([F:26])[cH:25]3)[cH:6][cH:7]1.[F:28][c:29]1[cH:30][c:31]([C:32]#[N:33])[cH:34][cH:35][c:36]1[OH:37].[N:38]([C:39]([O:40][C:41]([CH3:42])([CH3:43])[CH3:44])=[O:45])=[N:46][C:47]([O:48][C:49]([CH3:50])([CH3:51])[CH3:52])=[O:53]>>[Cl:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[n:9][c:10]3[c:11]([n:12]2[CH:13]([CH2:14][O:15][c:36]2[c:29]([F:28])[cH:30][c:31]([C:32]#[N:33])[cH:34][cH:35]2)[CH:16]2[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21]2)[cH:22][c:23]([F:27])[c:24]([F:26])[cH:25]3)[cH:6][cH:7]1

Participants

4

Reactant 3

HCID 97268Di-tert-butyl azodicarboxylateHCID 27829443-Fluoro-4-hydroxybenzonitrileHCID 666193102-[2-(4-Chloro-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-2-cyclohexyl-ethanol

Product 1

HCID 666194454-{2-[2-(4-Chloro-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-2-cyclohexyl-ethoxy}-3-fluoro-benzonitrile

Sources & evidence

ORD record
ord-40d41d9f8255464a9aaf5035fdde22c1
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Linked notes

Loading…