4-Amino-1-butanol → HCID 19864525, compound
Reaction equation
[CH3:1][C:2]1O[C:4]([CH3:7])=[N:5][N:6]=1.[NH2:8][CH2:9][CH2:10][CH2:11][CH2:12][OH:13]>CN1CCCC1=O>[CH3:1][C:2]1[N:8]([CH2:9][CH2:10][CH2:11][CH2:12][OH:13])[C:4]([CH3:7])=[N:5][N:6]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
2,5-Dimethyl-1,3,4-oxadiazole (3.8 g), 4-aminobutanol (3.5 g) and N-methylpyrrolidone (10 ml) were heated at 150° for 18 hours. The mixture was evaporated under high vacuum and the residue chromatographed on silica eluting with a mixture of ethyl acetate and methanol. The fractions containing the product were evaporated under vacuum to leave the title compound, (5.1 g), which was used directly.
Workup
- customThe mixture was evaporated under high vacuum
- customthe residue chromatographed on silica eluting with a mixture of ethyl acetate and methanol
- additionThe fractions containing the product
- customwere evaporated under vacuum
Sources & evidence
- ORD record
- ord-2c839f4aff904142bcafac9adb3c4cd1
- Source dataset
- uspto-grants-1990_02
- Patent number
- US04904671
Reaction notes
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