Hydrochloric Acid → Methyl 5-chloro-3-hydroxythiophene-2-carboxylate
Reaction equation
Cl[C:2]1([C:8]([O:10][CH3:11])=[O:9])[C:6](=[O:7])[CH:5]=[CH:4][S:3]1.[ClH:12]>C(O)(=O)C>[Cl:12][C:4]1[S:3][C:2]([C:8]([O:10][CH3:11])=[O:9])=[C:6]([OH:7])[CH:5]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of 2-chloro-2-methoxycarbonylthiophene-3(2H)-one (30 mmol) in acetic acid (20 ml) was saturated with dry hydrogen chloride gas. After standing for 3 days the solvent was removed under reduced pressure and the oily residue distilled to give a yellow liquid which crystallised on addition of aqueous acetic acid (m.p. 42°-44° C.).
Workup
- customthe solvent was removed under reduced pressure
- distillationthe oily residue distilled
- customto give a yellow liquid which
- customcrystallised on addition of aqueous acetic acid (m.p. 42°-44° C.)
Sources & evidence
- ORD record
- ord-54ac88c49b634371b5a37340dd9d777a
- Source dataset
- uspto-grants-1990_02
- Patent number
- US04904686
Reaction notes
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