Dichloromethane → 6-methoxy-4-[(3-methyl-1H-indol-5-yl)oxy]-7-[(piperidin-4-yl)methoxy]quinazoline

Reaction equation

[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH2:10][CH:11]([CH2:14][O:15][c:16]2[c:17]([O:37][CH3:38])[cH:18][c:19]3[c:20]([O:26][c:27]4[cH:28][c:29]5[c:30]([CH3:36])[cH:31][nH:32][c:33]5[cH:34][cH:35]4)[n:21][cH:22][n:23][c:24]3[cH:25]2)[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[Cl:46][CH2:47][Cl:48].[F:39][C:40]([F:41])([F:42])[C:43]([OH:44])=[O:45]>>[NH:8]1[CH2:9][CH2:10][CH:11]([CH2:14][O:15][c:16]2[c:17]([O:37][CH3:38])[cH:18][c:19]3[c:20]([O:26][c:27]4[cH:28][c:29]5[c:30]([CH3:36])[cH:31][nH:32][c:33]5[cH:34][cH:35]4)[n:21][cH:22][n:23][c:24]3[cH:25]2)[CH2:12][CH2:13]1