Acetic Acid → 4-((((1,1-Dimethylethyl)(dimethyl)silyl)oxy)methyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-2-carbaldehyde

HRID 120224

Reaction equation

HRID 120224 reaction equation
[C:30]([OH:31])(=[O:32])[CH3:33].[C:34]([OH:35])(=[O:36])[CH3:37].[CH3:1][C:2]([CH3:3])([CH3:4])[Si:5]([O:6][CH2:7][c:8]1[cH:9][c:10]([CH2:23][OH:24])[c:11](-[c:14]2[c:15]([F:22])[cH:16][cH:17][c:18]([O:20][CH3:21])[cH:19]2)[cH:12][cH:13]1)([CH3:25])[CH3:26].[CH3:45][C:46]1([CH3:55])[N:47]([O:48])[C:49]([CH3:50])([CH3:51])[CH2:52][CH2:53][CH2:54]1.[CH3:56][CH2:57][O:58][C:59]([CH3:60])=[O:61].[Cl:27][CH2:28][Cl:29].[I:38][c:39]1[cH:40][cH:41][cH:42][cH:43][cH:44]1>>[CH3:1][C:2]([CH3:3])([CH3:4])[Si:5]([O:6][CH2:7][c:8]1[cH:9][c:10]([CH:23]=[O:24])[c:11](-[c:14]2[c:15]([F:22])[cH:16][cH:17][c:18]([O:20][CH3:21])[cH:19]2)[cH:12][cH:13]1)([CH3:25])[CH3:26]

Participants

7

Reactant 6

HCID 176Acetic Acid2×HCID 6344DichloromethaneHCID 8857Ethyl AcetateHCID 11575IodobenzeneHCID 5499762,2,6,6-Tetramethylpiperidin-1-olHCID 57706179(4-((((1,1-Dimethylethyl)(dimethyl)silyl)oxy)methyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-2-yl)methanol

Product 1

HCID 577066184-((((1,1-Dimethylethyl)(dimethyl)silyl)oxy)methyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-2-carbaldehyde

Sources & evidence

ORD record
ord-dbee4140b94a4a0c8a71d69192cfafba
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Linked notes

Loading…