Tetrahydrofuran → 8-Bromo-2,3-dihydro-[1,4]dioxino[2,3-b]pyridine

Reaction equation

[Br:16][C:17]([F:18])([F:19])[C:20]([Br:21])([F:22])[F:23].[CH2:11]([Li:12])[CH2:13][CH2:14][CH3:15].[O:1]1[CH2:2][CH2:3][O:4][c:5]2[n:6][cH:7][cH:8][cH:9][c:10]21.[O:24]1[CH2:25][CH2:26][CH2:27][CH2:28]1>>[O:1]1[CH2:2][CH2:3][O:4][c:5]2[n:6][cH:7][cH:8][c:9]([Br:16])[c:10]21

Participants

Reactant 4

HCID 8028Tetrahydrofuran

HCID 313011,2-Dibromo-1,1,2,2-tetrafluoroethane

HCID 110079682,3-Dihydro-1,4-dioxino[2,3-b]pyridine

HCID 178418339Butyllithium

Product 1

HCID 687024548-Bromo-2,3-dihydro-[1,4]dioxino[2,3-b]pyridine

Sources & evidence

ORD record: ord-3a781f9df7ef4397ae2b296d0587322b
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (5/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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