Pyridine → Tert-butyl 3-(benzyloxy)-1-oxa-8-azaspiro[4.5]decane-8-carboxylate

HRID 120740

Reaction equation

HRID 120740 reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][CH:9]([CH2:10][C:11]1([OH:24])[CH2:12][CH2:13][N:14]([C:17](=[O:18])[O:19][C:20]([CH3:21])([CH3:22])[CH3:23])[CH2:15][CH2:16]1)[CH2:25][OH:26].[S:27]([Cl:28])([c:29]1[cH:30][cH:31][c:32]([CH3:33])[cH:34][cH:35]1)(=[O:36])=[O:37].[cH:38]1[cH:39][cH:40][n:41][cH:42][cH:43]1>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][CH:9]1[CH2:10][C:11]2([CH2:12][CH2:13][N:14]([C:17](=[O:18])[O:19][C:20]([CH3:21])([CH3:22])[CH3:23])[CH2:15][CH2:16]2)[O:24][CH2:25]1

Participants

4

Reactant 3

HCID 1049PyridineHCID 73974-Toluenesulfonyl chlorideHCID 22744648Tert-butyl 4-[2-(benzyloxy)-3-hydroxypropyl]-4-hydroxy-1-piperidinecarboxylate

Product 1

HCID 22744533Tert-butyl 3-(benzyloxy)-1-oxa-8-azaspiro[4.5]decane-8-carboxylate

Sources & evidence

ORD record
ord-c4b8c61769cd4f0a8a40a0daccc6aa21
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Linked notes

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