Bicarbonate Ion → tert-Butyl 4-(((4'-cyano-5-(trifluoromethyl)biphenyl-3-yl)methoxy)methyl)-4-(pyridin-4-yl)piperidine-1-carboxylate
Reaction equation
[Br:1][CH2:2][c:3]1[cH:4][c:5](-[c:13]2[cH:14][cH:15][c:16]([C:19]#[N:20])[cH:17][cH:18]2)[cH:6][c:7]([C:9]([F:10])([F:11])[F:12])[cH:8]1.[C:53](=[O:54])([OH:55])[O-:56].[CH3:42][C:43]([CH3:44])([O-:45])[CH3:46].[K+:47].[Na+:57].[O:48]1[CH2:49][CH2:50][CH2:51][CH2:52]1.[OH:21][CH2:22][C:23]1([c:36]2[cH:37][cH:38][n:39][cH:40][cH:41]2)[CH2:24][CH2:25][N:26]([C:29](=[O:30])[O:31][C:32]([CH3:33])([CH3:34])[CH3:35])[CH2:27][CH2:28]1>>[CH2:2]([c:3]1[cH:4][c:5](-[c:13]2[cH:14][cH:15][c:16]([C:19]#[N:20])[cH:17][cH:18]2)[cH:6][c:7]([C:9]([F:10])([F:11])[F:12])[cH:8]1)[O:21][CH2:22][C:23]1([c:36]2[cH:37][cH:38][n:39][cH:40][cH:41]2)[CH2:24][CH2:25][N:26]([C:29](=[O:30])[O:31][C:32]([CH3:33])([CH3:34])[CH3:35])[CH2:27][CH2:28]1Participants
8
Reactant 7
Product 1
Sources & evidence
- ORD record
- ord-e0b968872b984d16bf87d722269ad766
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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