Hydrochloric Acid → 3-(Aminomethyl)-5-bromobenzonitrile

Reaction equation

[Br:1][c:2]1[cH:3][c:4]([C:5]#[N:6])[cH:7][c:8]([CH2:10][N:11]2[C:12](=[O:13])[c:14]3[c:15]([cH:16][cH:17][cH:18][cH:19]3)[C:20]2=[O:21])[cH:9]1.[CH3:23][CH2:24][OH:25].[CH3:26][OH:27].[ClH:22]>>[Br:1][c:2]1[cH:3][c:4]([C:5]#[N:6])[cH:7][c:8]([CH2:10][NH2:11])[cH:9]1

Participants

Reactant 4

HCID 313Hydrochloric Acid

HCID 702Ethanol

HCID 887Methanol

HCID 578134473-Bromo-5-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]benzonitrile

Product 1

HCID 578133373-(Aminomethyl)-5-bromobenzonitrile

Sources & evidence

ORD record: ord-d8fb4ac6df864010a16e915cc5bc1a42
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (5/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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